In the past several years, there has been rapid growth in the number of clinical hyperbaric facilities, due in part to the availability of the monoplace, or single-person, hyperbaric chamber and the proliferation of outpatient wound care centers. Monoplace chambers are relatively inexpensive, require fewer personnel, and require less space to operate and maintain than multiplace (walk-in) chambers. Another advantage of the monoplace over the multiplace chamber is that attendants need not enter the hyperbaric chamber with the patient. However, some hyperbaric physicians express concerns about treating unstable or critically ill patients in the monoplace chamber, because of the lack of “hands-on” care during hyperbaric exposure, the lack of suitable equipment for optimal patient care, and the limitations of treatment pressures to 3 atmospheres absolute pressure (ATA). We have found that with a well-trained staff and the availability of appropriate equipment, critically ill patients can be treated safely in the monoplace chamber. We, and others, have presented monoplace chamber use in critically ill patients. Anyone who anticipates treating critically ill patients in a monoplace chamber should be familiar with this work.